On the possibility of therapeutic action after transdermal patch application

Background . As scientific knowledge about the peculiarities of structure and functional properties skin increased, it became clearer that during transdermal administration, drug may accumulate in deep layers dermis subsequently get diffused into bloodstream even after therapeutic system (TTS), also called patch, had been removed. Objective : to quantify active substances remaining an animal TTS application. Materials methods Two previously developed patches containing Russian-made were chosen for study: aminodihydrophthalazinedione sodium (immunomodulator) bis(1-vinylimidazole-N) zinc diacetate (antidote carbon monoxide). The study was performed on male Chinchilla rabbits weighing 2.5–3 kg. Five series experiments each substance: immediately removal 4 hours later, at week 1, 2 3 removal. High-performance liquid chromatography atomic absorption spectroscopy used residual left skin. Results In flap contact with 24 hours, 0.516 mg detected patch. Over next two weeks, substance decreased immunomodulator significantly reducing 0.41 first hours. 1 present patch Four quantity remained practically unchanged. At 2, antidote slightly ~0.7 ~0.25 mg, respectively. Conclusion For application sodium, can act as a depot prolong effect this No such found case diacetate, which is apparently due different solubility drugs biotissue.